Guanidinium Chloride
Guanidinium Chloride - General Information
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. [PubChem]
Pharmacology of Guanidinium Chloride
Guanidinium Chloride apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Guanidinium Chloride for patients
Guanidinium Chloride Interactions
Guanidinium Chloride Contraindications
Guanidine is contraindicated in individuals with a history of intolerance or allergy to this drug.
Additional information about Guanidinium Chloride
Guanidinium Chloride Indication: For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Mechanism Of Action: Not Available
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Guanidine
Synonyms: Not Available
Drug Category: Parasympathomimetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Guanidine: Aminomethanamidine; Carbamamidine; Carbamidine; Guanidin; Guanidine Hydrochloride; Guanidinium Chloride; Guanidinium Sulfate; Imidourea; Iminourea;
Absorption: Rapidly absorbed and distributed
Toxicity (Overdose): LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Protein Binding: Not Available
Biotransformation: Not metabolized.
Half Life: 7-8 hours
Dosage Forms of Guanidinium Chloride: Not Available
Chemical IUPAC Name: guanidine
Chemical Formula: CH5N3
Guanidine on Wikipedia: https://en.wikipedia.org/wiki/Guanidine
Organisms Affected: Humans and other mammals
